![]() ![]() ![]() By time estimation, it was found that the inactivation of UCP1 in cetaceans occurred between 53.1 and 50.2 Ma. Here, frameshift mutations, premature termination, and relaxed selection pressure ( ω = 0.9557, P < 0.05) were detected in UCP1 in cetaceans, suggesting that UCP1 was inactivated during cetacean evolution. However, the relationship between the evolution of UCP1 and fat deposition in the blubber layer in cetaceans remains unclear. Uncoupling protein 1 ( UCP1) is an essential protein in the mitochondrial inner membrane that mediates nonshivering thermogenesis (NST) and plays an important role in thermoregulation and fat deposition. ![]()
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